%PDF-1.6
%
1 0 obj
<>>>
endobj
2 0 obj
<>stream
2017-08-04T09:58:52+02:00
2017-08-04T09:58:52+02:00
2017-08-04T09:58:52+02:00
Adobe InDesign CC 2014 (Windows)
uuid:e564399b-5b7d-4eda-8e8d-4a197a09cefb
xmp.did:df32751f-6152-0745-abb3-8322afe28d09
xmp.id:c8fa930a-c4a7-8045-9914-501d26d1afbc
proof:pdf
converted
from application/x-indesign to application/pdf
Adobe InDesign CC 2014 (Windows)
/
2017-08-04T09:58:52+02:00
xmp.iid:0d4931f9-0ee0-4442-b4e1-51cd11412258
xmp.did:df32751f-6152-0745-abb3-8322afe28d09
xmp.did:df32751f-6152-0745-abb3-8322afe28d09
default
application/pdf
Adobe PDF Library 11.0
False
endstream
endobj
3 0 obj
<>
endobj
5 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 595.276 841.89]/Type/Page>>
endobj
6 0 obj
<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 595.276 841.89]/Type/Page>>
endobj
16 0 obj
<>stream
q
/GS0 gs
20.4094485 0 0 20.4094485 288 16.648657 cm
/Im0 Do
Q
BT
0 0 0 1 k
/GS1 gs
/T1_0 1 Tf
10 0 0 10 60.2362 750.4468 Tm
[(5.)37( Objectives and )]TJ
0 -1.2 TD
[(timescale,)37.1( funding )]TJ
T*
(and division of )Tj
T*
(labour)Tj
0 -9.988 TD
[(7.)37( Educa)-10(tion and )]TJ
0 -1.2 TD
(training)Tj
9.661 14.788 Td
(Arrange meetings with all relevant staff when early plans for the projec\
t exist.)Tj
-0.045 Tw 0 -1.6 TD
[(Construct an a)-10(pproxima)-9.9(te timescale for the project,)37( indica)-9.9(ting the need for assistance with prepara)-9.9(tion,)37( )]TJ
0 Tw T*
[(animal care,)37.1( procedures and waste disposal/decontamina)-9.6(tion.)]TJ
T*
[(Discuss and disc)20.1(lose all expected and potential costs.)]TJ
T*
[(Construct a detailed plan for division of labour and expenses a)-9.5(t all sta)-9.9(ges of the stud)-9.8(y)55(.)]TJ
0.033 Tw 0 -7.188 TD
[(Assess the current competence of staff members and the need for further \
educa)-10(tion or training prior )]TJ
0 Tw 0 -1.6 TD
[(to the stud)-9.9(y)55(.)]TJ
ET
1 0.858 0.064 0.305 k
/GS0 gs
51.968 795.945 491.339 24.331 re
f
0.601 0.261 0 0 k
51.968 767.894 491.339 29.409 re
f
51.968 482.134 491.339 29.409 re
f
BT
0 0 0 0 k
/T1_1 1 Tf
0.03 Tc 6.191 Tw 10 0 0 10 60.2362 804.7794 Tm
[(T)74(opic)]TJ
/Span<>> BDC
( )Tj
EMC
(Recommendation)Tj
0 0 0 1 k
/GS1 gs
0 Tw 12 0 0 12 158.0501 779.1329 Tm
[(\(B\) Dialogue between scientists and the animal f)20(acility)]TJ
1.047 -23.813 Td
(\(C\) Quality control of the components in the study)Tj
ET
0 0 0 1 K
0.5 w 4 M
q 1 0 0 1 136.063 767.8937 cm
0 0 m
0 -645.669 l
S
Q
q 1 0 0 1 51.9685 767.8937 cm
0 0 m
0 -645.669 l
S
Q
q 1 0 0 1 543.057 767.8937 cm
0 0 m
0 -645.669 l
S
Q
1 w
q 1 0 0 1 51.9685 675.0906 cm
0 0 m
491.339 0 l
S
Q
q 1 0 0 1 51.9685 631.8583 cm
0 0 m
491.339 0 l
S
Q
q 1 0 0 1 51.9685 588.6141 cm
0 0 m
491.339 0 l
S
Q
q 1 0 0 1 51.9685 439.0039 cm
0 0 m
491.339 0 l
S
Q
q 1 0 0 1 51.9685 393.9567 cm
0 0 m
491.339 0 l
S
Q
q 1 0 0 1 51.9685 350.3268 cm
0 0 m
491.339 0 l
S
Q
q 1 0 0 1 50.5512 288.4173 cm
0 0 m
491.339 0 l
S
Q
q 1 0 0 1 51.9685 227.9252 cm
0 0 m
491.339 0 l
S
Q
q 1 0 0 1 51.9685 165.4016 cm
0 0 m
491.339 0 l
S
Q
q 1 0 0 1 51.9685 121.7244 cm
0 0 m
491.339 0 l
S
Q
0.5 w
141.746 750.707 9.671 7.37 re
S
141.746 614.831 9.671 7.37 re
S
BT
/T1_0 1 Tf
0 Tc 10 0 0 10 60.2362 377.1161 Tm
[(11.)37( Quarantine and )]TJ
0 -1.2 TD
(health monitoring)Tj
-0.01 Tc 9.661 1.2 Td
[(Discuss the animals\222 likely health sta)-10(tus,)37( an)-10(y needs for transport,)37( quarantine and isola)-10(tion,)27( )]TJ
0 -1.6 TD
(health monitoring and consequences for the personnel.)Tj
ET
141.746 377.376 9.671 7.37 re
S
BT
0 Tc 10 0 0 10 60.2362 148.0059 Tm
[(15.)37( Necropsy)]TJ
-0.01 Tc 9.661 0 Td
[(Construct a systema)-10(tic plan for all sta)-10(ges of necropsy)55(,)37( inc)20(luding loca)-9.9(tion,)37( and identi\037ca)-10(tion of all)-10( )]TJ
T*
(animals and samples.)Tj
ET
141.746 147.293 9.671 7.37 re
S
BT
0 Tc 10 0 0 10 60.2362 270.7106 Tm
[(13.)37( Experimental )]TJ
0 -1.2 TD
(procedures)Tj
-0.01 Tc 9.661 1.2 Td
[(Develop re\037ned procedures for ca)-9.9(pture,)37.1( immobilisa)-10(tion,)37( marking,)37( and release or re-homing.)]TJ
0 -1.6 TD
[(Develop re\037ned procedures for substance administra)-10(tion,)37( sampling,)37( seda)-9.9(tion and anaesthesia,)37.1( surger)-17.9(y)-10( )]TJ
T*
(and other techniques.)Tj
ET
141.746 270.148 9.671 7.37 re
S
141.746 254.018 9.671 7.37 re
S
BT
0 Tc 10 0 0 10 60.2362 209.8208 Tm
[(14.)37( Humane killing,)37.1( )]TJ
0 -1.2 TD
[(release,)37.1( re-use or )]TJ
T*
(re-homing)Tj
-0.01 Tc 9.661 2.4 Td
[(Consult relevant legisla)-10(tion and guidelines well in advance of the stud)-10(y)55(.)]TJ
0 -1.6 TD
[(De\037ne primar)-18(y and emergenc)20(y methods for humane killing.)]TJ
T*
[(Assess the competence of those who may ha)-10(ve to perform these tasks.)]TJ
ET
141.746 209.305 9.671 7.37 re
S
141.746 193.242 9.671 7.37 re
S
141.746 177.179 9.671 7.37 re
S
BT
0 Tc 10 0 0 10 60.2362 332.4921 Tm
[(12.)37( Housing and )]TJ
0 -1.2 TD
[(husbandr)-17.9(y)]TJ
-0.01 Tc 9.661 1.2 Td
[(Attend to the animals\222 speci\037c instincts and needs,)37( in collabora)-9.9(tion with expert staff.)]TJ
0 -1.6 TD
[(Discuss acc)20(lima)-9.9(tion,)37( optimal housing conditions and procedures,)37( environmental factors and an)-10(y)-10( )]TJ
T*
[(experimental limita)-10(tions on these \(e.g.)37( food depriva)-9.9(tion,)37( solitar)-17.9(y housing\).)]TJ
ET
141.746 332.752 9.671 7.37 re
S
141.746 315.941 9.671 7.37 re
S
BT
0 Tc -0.037 Tw 10 0 0 10 60.2362 464.9606 Tm
[(9.)37( T)74(est )-37(substances )]TJ
0 Tw 0 -1.2 TD
(and procedures)Tj
9.661 1.2 Td
[(Provide as much informa)-9.8(tion as possible about test substances.)]TJ
0 -1.6 TD
(Consider the feasibility and validity of test procedures and the skills \
needed to perform them.)Tj
ET
141.746 465.22 9.671 7.37 re
S
141.746 448.766 9.671 7.37 re
S
BT
10 0 0 10 60.2362 421.6122 Tm
[(10.)37( Experimental )]TJ
0 -1.2 TD
(animals)Tj
9.661 1.2 Td
[(Decide upon the characteristics of the animals tha)-9.6(t are essential for the stud)-9.7(y and for reporting.)]TJ
0 -1.6 TD
[(Avoid genera)-9.9(tion of surplus animals.)]TJ
ET
141.746 421.163 9.671 7.37 re
S
141.746 405.417 9.671 7.37 re
S
141.746 702.175 9.671 7.37 re
S
BT
10 0 0 10 60.2362 657.315 Tm
[(6.)37( F)20(acility )]TJ
0 -1.2 TD
[(evalua)-9.9(tion)]TJ
-0.051 Tw 9.661 1.2 Td
[(Conduct a physical inspection of the facilities,)37.1( to evalua)-10(te building and equipment standards and needs.)]TJ
0 Tw 0 -1.6 TD
[(Discuss staf\037ng levels a)-9.8(t times of extra risk.)37.2( )]TJ
ET
141.746 656.866 9.671 7.37 re
S
141.746 641.018 9.671 7.37 re
S
141.746 685.632 9.671 7.37 re
S
BT
10 0 0 10 60.2362 570.3366 Tm
[(8.)37( Health risks,)37.1( )]TJ
0 -1.2 TD
(waste disposal and )Tj
T*
[(decontamina)-9.9(tion)]TJ
-0.041 Tw 9.661 2.4 Td
[(P)18(erform a risk assessment,)37.1( in collabora)-10(tion with the animal facility)55.1(,)37( for all persons and animals affected )]TJ
0 Tw 0 -1.6 TD
[(directly or indirectly by the stud)-9.7(y)55(.)]TJ
T*
[(Assess,)37( and if necessar)-17.8(y produce,)37( speci\037c guidance for all sta)-9.7(ges of the project.)]TJ
T*
[(Discuss means for containment,)37.2( decontamina)-9.8(tion,)37( and disposal of all items in the stud)-9.7(y)55(.)]TJ
ET
141.746 570.077 9.671 7.37 re
S
141.746 538.037 9.671 7.37 re
S
141.746 522.014 9.671 7.37 re
S
141.746 733.978 9.671 7.37 re
S
BT
/T1_2 1 Tf
10 0 0 10 52.2185 104.0886 Tm
(References)Tj
/T1_0 1 Tf
0.03 Tc 8 0 0 8 52.2185 93.0886 Tm
(1.)Tj
/Span<>> BDC
0.743 0 Td
( )Tj
EMC
0.757 0 Td
[(Smith )37(AJ,)37( Clutton RE,)37( Lilley E,)37( Hansen KEA & Bra)-9.9(ttelid )37(T)92(.)37( PREP)37(ARE:Guidelines for Planning )37(Animal Research and )37(T)74(esting.)67( )]TJ
0 Tc /Span<>> BDC
-1.5 -1.375 Td
( )Tj
EMC
/T1_2 1 Tf
0.03 Tc -0.037 Tw 1.5 0 Td
[(Labora)-9.9(tor)-18(y Animals,)]TJ
/Span<>> BDC
7.888 0 Td
( )Tj
EMC
/T1_0 1 Tf
0 Tw 0.27 0 Td
[(2017,)37( DOI:)37( 10.1177/0023677217724823.)]TJ
-9.658 -1.375 Td
(2.)Tj
/Span<>> BDC
0.743 0 Td
( )Tj
EMC
0.757 0 Td
[(Kilkenn)-10(y C,)37( Bro)-10(wne )37(WJ,)37( Cuthill IC )]TJ
/T1_2 1 Tf
(et al.)Tj
/T1_0 1 Tf
[( Improving Bioscience Research Reporting:)37( )37(The )37(ARRIVE Guidelines for Reporting )37(Animal Research.)67( )]TJ
0 Tc /Span<>> BDC
-1.5 -1.375 Td
( )Tj
EMC
/T1_2 1 Tf
0.03 Tc 1.5 0 Td
[(PloS Biolog)-10(y)55(,)]TJ
/T1_0 1 Tf
[( 2010; DOI:)37( 10.1371/journal.pbio.1000412.)67( )]TJ
/T1_2 1 Tf
10 0 0 10 52.2185 34.2421 Tm
[(Further informa)-10(tion)]TJ
1 0.858 0.064 0.305 k
/GS0 gs
-0.03 Tw 0 -1.1 TD
[(https://norecopa.no/PREP)37(ARE)]TJ
0 0 0 1 k
/GS1 gs
0 Tw ( | )Tj
1 0.858 0.064 0.305 k
/GS0 gs
-0.03 Tw (post@norecopa.no)Tj
0 0 0 1 k
/GS1 gs
0 Tw ( | )Tj
1 0.858 0.064 0.305 k
/GS0 gs
-0.03 Tw (@norecopa)Tj
ET
endstream
endobj
17 0 obj
<>/Filter/FlateDecode/Height 86/Intent/RelativeColorimetric/Length 2681/Name/X/Subtype/Image/Type/XObject/Width 86>>stream
HW{PT?6syWĪQֱMil2LǤMc2D3tL6H#m:MfJ/@`y>>P*
Dc=w{^v1939DEQDEQDn4H9,^X%I>D#{
UԓSLa%2dyj#}j/2dGVbGęN?90|!Ɇbhv!~zC#ۋ<7u}<\e
[Q;|/j &%W'ʉVtzWPr
Z@D;NÅ!a!؞lYf>&MXKwSiHevc Zx!⊃tMV}t@h^ quz#HmSB@h2;pL.)9.ux3`![^+0n*ln@A"#E˪A&EoC0##ٽLJ)C=|3?&F7an
IMLh`MW|\/LP4'LUh veՉ kS1S`N66qd>:1YSV+!fxo4'wdil0㗥z0cC
=:fG=+3+